NAT4MORE

2017 - 2020

Natural molecules on the surface of bioactive materials for modulating the host response to implants.

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Development of nanotextured surfaces for bone implants, functionalized with natural biomolecules, able to fine modulate the host response and reduce infections, tested for packaging, sterilization, shelf life and durability in physiological working conditions. Established bone implant materials (titanium alloys, bioactive glasses and hydroxyapatite) were selected as substrates. Surface functionalization will follow a bioinspired approach by using polyphenols derived from grape pomace and chitin derivatives from shrimp shells, with proven anti-oxidant, anti-inflammatory, antibacterial and bone stimulating activity.

Role in project

Project management among Icelandic partners.

Specification / Preparation of hydroxyapatite substrates for coating.

Application of chitin derivative coatings on bioactive glass, hydroxyapatite and titanium alloy surfaces.

Characterization of surfaces and of chitin derivative coatings on surfaces: FESEM-EDS, optical profilometry (µm roughness), contact angle, Raman microscopy; FT-IR microscopy and AFM (at the University of Iceland).

Organization of in vivo experiments in cooperation with Genís.

x-ray µCT analysis of samples from in vivo experiments.

Mechanical tests: implant-bone interface.

Partners

BRASIL

- Universidade de São Paulo

ICELAND

- Genís hf.

ITALY

- Politecnico di Torino
- Consiglio per la Ricerca in agricoltura e l’analisi dell’Economia Agraria

Acknowledgements

This project has received funding from the Icelandic Technology Development Fund.

Dedicated website

Contact

Gissur Örlygsson

gissur [at] taeknisetur.is